Introduction: Viral hepatitis B is a major public health problem. The objective of this work was to study the prevalence of viral co-infections C, D and HIV in patients with viral hepatitis B. 

Materials and Methods: This was a descriptive cross-sectional study carried out in one phase, from January 1 to December 31, 2023, i.e. a duration of 12 months within the medical analysis laboratory of the Pasteur Institute in Bangui.

Results: We have listed1049 patients during the study period The 21-40 age group was the most represented with a number of 496 (47.3%) as well as the male gender 564 (53.8%). HBV and HDV coinfection (22.2%). Among the 158 HBsAg-positive patients screened for HCV, 11 (7%). HBV/HCV/HDV coinfection was found in 0.7% of cases.

Conclusion: The prevalence of hepatitis B is considerable and confirms that our country is part of the area of high endemicity of hepatitis B virus infection.