Superior mesenteric artery syndrome (SMAS) is a rare cause of duodenal obstruction resulting from compression of the third portion of the duodenum etween the aorta and the superior mesenteric artery (SMA), with nonspecific clinical manifestations that may be similar to functional dyspepsia or eating disorders, which often delays diagnosis. We present the case of a young fitness trainer who presented with early postprandial satiety, abdominal pain that improved in the genupectoral position, and progressively worsening intolerance to oral intake, associated with a weight loss of 9 kg in one year. Endoscopic evaluation and CT angiography revealed a reduced aortomesenteric angle and duodenal compression consistent with SMAS. She underwent laparoscopic duodenojejunostomy with a favorable postoperative course, adequate oral tolerance, and weight regain. This case highlights the importance of maintaining a high index of clinical suspicion in young patients with weight loss and nonspecific symptoms of obstruction; once the diagnosis is confirmed, the safest and most effective surgical option in treatment-refractory cases is minimally invasive duodenojejunostomy.