Aim: To assess efficacy of PRP on wound healing and pain perception after elective cesarean section (CS) in high-risk population.

Material and Methods: 112 patients were admitted for elective CS. Participants were randomly equally assigned into two groups. In study group, prior to skin closure 5 ml PRP was applied to subcutaneous tissue by micro-injections. In control group, subcutaneous tissue was cleaned with normal saline only. Primary endpoint used Visual Analogue Scale (VAS) for pain intensity and REEDA scale (redness, edema, ecchymosis, discharge, approximation) for wound healing. Secondary outcome were Vancouver scar scale (VSS) for Scar quality and overall satisfaction using numeric scale. All participants were evaluated at day 1, day 7 and at sixth weeks after CS.

Results: Although pain was not statistically significantly different between both groups; surprisingly, study patients required fewer analgesics doses per day than the control group: 39.3% in the PRP group and 58.9% in the control group (P=0.03). PRP group showed a greater reduction in REEDA score compared to the control group (P=0.001). Significant differences between both groups in the scar quality assessment by VSS in the favor of the PRP group (P < 0.001).

Conclusion: Confirmation of PRP’s usefulness in improving wound healing, scare quality and reduction of analgesics after CS in the high-risk population may further lead to the implementation into ERAS protocols and everyday clinical practice.