According to current bibliography, many cases of congenital entities are properly diagnosed and treated due to increased steps of fetal medicine. Ultrasound measuring of NT (Nuchal Translucency) or B level scanning depicts many aspects of fetal lesions. Anencephaly consists one severe and lethal congenital fetal lesion. Ultrasound imaging findings reveal absence of cranial structures, cornerstone of this lesion. The most predisposition factor concerning the diagnosis of such cases represents the level of experience of the fetal medicine specialist.

Aim of our study consists presentation of a case of dichorionic, diamnionic twin pregnancy discordant for anencephaly. Ultimate scope of our depiction reflects proper diagnosis and assiduous therapeutic mapping concerning the viability of the other fetus due to lethal conclusion of the pathologic one.