The World Health Organization (WHO) defines infertility as a disease characterized by the absence of pregnancy after 12 or more months of regular unprotected sex. Couple infertility is an increasingly present problem in today’s society. We present a case of a patient with assisted reproduction program complicated with uterus altered by numerous fibroids who obstructed routine transvaginal oocyte retrival. Routine transvaginal procedure of oocyte retrival was impossible due to the size and shape of the uterus altered by numerous fibroids. The aspiration was done by transabdominal ultrasound-guided follicular aspiration. A successful embryo transfer was performed without complications. Patient was successfully delivered at 32 weeks of gestation. Main objective of this case report is to bring to the light the challenging situations that infertility specialist face, and alternative solutions that deviate from the daily routine but bring the final desired result – birth of the healthy newborn.