Gestational Trophoblastic Disease (GTD) is a clinical entity characterized by abnormal cell proliferation affecting cells of trophoblastic tissue. Within the spectrum of the disease, Complete Hydatidiform Mole and Partial Hydatidiform Mole are the most common entities. However, cases of Hydatidiform Mole concurrent with twin pregnancy are rare.

The present report aims to describe a case of twin pregnancy in an 18-year-old patient, consisting of a normal fetus and placenta associated with a Partial Hydatidiform Mole, which progressed to miscarriage around the 17th week of gestation, covering from the moment of presentation at the Emergency Room to outpatient follow-up post-hospital discharge.