The ultrasonographic markers are less sensitive and that the biochemical markers are not very beneficial. Various serum markers have been investigated as probable predictors in the first and second trimester of pregnancy. The markers utilized are both angiogenic and anti-angiogenic factors and related to the placentation. Appropriate screening for early-onset pre-eclampsia is reasonable in the first trimester of pregnancy with a high detection rate and a low false-positive rate. Furthermore, the biochemical markers are not very beneficial when used alone as a predictive tool of pre-eclampsia. A combination of the biochemical markers along with maternal history, clinical features, risk factors, demographic characteristics, Doppler velocimetry could be more effective in the prediction of pre-eclampsia. Besides, an antenatal check-up at 11-13 weeks when maternal risk factors and history is cumulatively assessed along with biophysical and biochemical parameters has been suggested by recent approaches.

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A combination of the biochemical markers and maternal history, clinical features, risk factors, demographic characteristics, and Doppler velocimetry could be more effective in predicting pre-eclampsia.