A crucial component of In-Vitro Fertilization (IVF) success is selection of excellent quality embryos for uterine transfer. The ability to correlate excellent quality embryos with successful implantation is diminished in women of advanced maternal age (AMA). In recent years, controversy has surrounded the universal use of preimplantation genetic screening (PGS) in women undergoing IVF. A 39-year-old Caucasian nulligravida with age related infertility underwent an unsuccessful fresh IVF cycle that was followed by the unusually poor survival of morphologically good quality frozen blastocysts. Subsequently, she underwent a second IVF cycle with PGS of fresh blastocysts as well as blastocysts from the first IVF cycle. A successful transfer of euploid embryos resulted in a live birth. This case, although not conclusive, delineates the additional benefit of using PGS in women of advanced maternal age with poor survival of morphologically good quality embryos.