Aim: The primary targeted aim of this study was to elucidate, investigate and determine whether there is a potential correlation between ABO blood groups and the risk of Coronary Heart Disease (CHD).

Subjects and Methods: The study based case-control study design, included 1.191 CHD patients and 1,191 healthy individuals as controls, aged above 35 years males and females.

Results: Statistically notable differences were found between CHD and healthy control groups in terms of age (p = 0.025) , income (p = 0.003) BMI (p = 0.007) cigarette smoking (p = 0.014) water-pipe hookah-nargileh (p = 0.008) physical exercise (n = 0.003). metabolic syndrome-ATPIII (p < 0.001) and metabolic syndrome-IDF (p = 0.003) The blood group O was substantially significantly more prevalent in CHD patients as opposed to healthy population (36.6% vs 41.1%; p = 0.024). followed by A blood group common in CHD cases (34.4% vs 29.7%) further similarly in B blood group. Another similar distribution is seen in blood group AB in both groups (7.3% vs. 5.6%). The spread of ABO blood groups amid male CHD patients in contrast to healthy men, were more widespread and common in O (35.5% vs 42.9%, p = 0.012) and blood group A (34.1% vs 29.9%; p = 0.013) and B (24.1% vs 22.4; p = 0.05). Furthermore, Blood group AB was less common in male CHD patients (4.7% vs 6.8%) than in healthy men. More number of women with CHD had blood group O (37.6% vs 39.7%) and A (33.9% vs 29.5%) and B. (20.1% vs 24.5%).

Prominent and notable statistical differences in the biochemical parameters between CHD and healthy included: haemoglobin (p<0.001), vitamin D (p = 0.003) HbAic, (p < 0.001) FBG (p < 0.001) potassium (overline p < 0.001). calcium (p < 0.001) , Lymphocyte (p = 0.001) haematocrit (p<0.001), potassium (p = 0.026) Na (p < 0.001) creatinine (p < 0.001) cholesterol (p < 0.011) HDL (p = 0.002) LDL(p<0.001), bilirubin (p < 0.001) ferritin (p 0.007), triglyceride (p < 0.001) uric acid (0.001). C-reactive protein, (p < 0.001) SBP (p < 0.001) n and DBP (p<0.001).. A multivariate regression analysis identified the risk factors for CHD as diabetic (p < 0.001) sleep quality (p < 0.001) CRP (p < 0.001) triglyceride (p < 0.001) calcium (p < 0.001) cholesterol (p = 0.002) creatine kinase (p = 0.006) mean corpuscular volume (p = 0.007) mean platelet volume (overline p = 0.021) uric asid (p = 0.026) and cigarette smoking (p = 0.027) were predictors as significant determinants for CHD.

Conclusion: The study found a correlation between blood groups and coronary heart disease (CHD). Blood groups O and A were more prevalent among CHD patients compared to healthy individuals. The distribution of blood groups varied as O and B being more common in men and A and B being more frequent in women with CHD compared to healthy subjects.