Research Article

Exploring the Connections Between Autoimmune Disease and Obsessive Compulsive Disorder: Theoretical and Practical Approaches to Treatment

Authors: Eda Gorbis, Devon Jones, Alexander Gorbis, Joseph O'Neill, Amanda Rudolph.

DOI: 10.33425/2769-6294.1044

---

Abstract

Obsessive-compulsive disorder (OCD) is a debilitating neurological disorder that tends to have high comorbidity with other psychiatric illnesses, like anxiety (76% and depression 63%). While the causes of OCD have been historically believed to be genetic and environmental, we would like to bring to the forefront an immunological approach to understanding the etiology of the disorder. Here, we review the literature on autoimmune disease and the linkages to OCD by examining neuropsychiatric pathways, as well as inflammation of neuronal bodies within the Cortico-Striatalthalamus-Cortical (CSTC). We would like to call for the integration of immunologists and allergists as standard facets within patients with OCD treatment plans. Increased specificity within patient intake is vital, and including immunological factors is necessary to get an accurate picture of the patient. Along with behavioral and cognitive therapies, this multidisciplinary approach can help us deepen our understanding of the disorder as a whole and lead to better prognoses around the world.

View / Download PDF