In order to improve health care efficiency and effectiveness, treatments should provide disease improvement or resolution at reasonable cost. Furthermore, we should always think about patient-centered care in determining the best treatment for each patient’s condition. When considering the treatment options for CTS, only four treatments are supported by some evidence: splinting, steroids, ultrasound, and surgery. Splinting and steroids are useful as initial treatment for improving symptoms, but their effects are temporary. The evidence level for ultrasound treatment is poor and further investigations are needed. Moreover, early treatment using mini-OCTR appears to be the preferred treatment approach.