International Journal of Orthopedic Surgery & Research

International Journal of Orthopedic Surgery & Research

Open Access
ISSN: 3070-3972
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Research Article

Selection Criteria for Cytoreductive Surgery and Hipec for Treatment of Peritoneal Metastases

Authors: George Efthymiopoulos, Irina Noskova, John Spiliotis.

DOI: 10.33425/3070-3972.1009

Abstract

Peritoneal metastases (PM) from gastrointestinal and gynecological primaries pose a poor prognosis, but cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) offers potential survival benefits in select cases. This mini-review outlines key selection criteria: low disease burden (Peritoneal Cancer Index 70), manageable comorbidities, and favorable tumor biology. Completeness of cytoreduction (CC-0/1) is essential, best achieved in high volume centers. Preoperative assessment via CT, MRI, PET, and laparoscopy guides decisions, with 3-year survival ranging from 5-10% (gastric PM) to 50-60% (ovarian PM). Multidisciplinary expertise optimizes outcomes while minimizing risks.

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Citation: George Efthymiopoulos, Irina Noskova,  John Spiliotis. Selection Criteria for Cytoreductive Surgery and Hipec for Treatment of Peritoneal Metastases. 2025; 1(2). DOI: 10.33425/3070-3972.1009
Editor-in-Chief
Antonio Manenti
Antonio Manenti
Department of Surgery | University of Modena and Reggio Emilia
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Journal Metrics
Impact Factor 2.5*
Acceptance Rate 75%
Time to first decision 6-10 Days
Submission to acceptance 12-15 Days