Breath has a prime role in human mental and physical well-being. Alternating rhythms of the nasal cycle are connected to and govern the parasympathetic and sympathetic states of the autonomic nervous system (ANS). The ANS has a role in physiological, emotional, homeostatic, metabolic, and catecholamine regulation via the basic rest-activity cycle (BRAC). Hypoxia and disturbed nasal cycle lateralization may contribute to psychopathologies like schizophrenia. Deep breathing yoga exercises on a regular basis may be beneficial as a complementary therapy in restoring oxygen supply to brain neurons, correcting nasal cycle lateralization, and dealing with schizophrenia.