The study investigates the impact of Anapanasati meditation on the well-being of secondary school students in Teesta, Kalimpong district, West Bengal. Adolescents in rural areas often face rising stress, distraction, and emotional instability due to sociocultural and technological pressures. Employing a mixed-methods design with a convergent parallel approach, the study combined quantitative and qualitative data to assess changes in student well-being. Thirty-two students were randomly assigned to control and experimental groups, with the latter receiving a 21-day guided meditation intervention structured into grounding, breath anchoring, and mindfulness practice phases. The Well-being Index by Chauhan & Sharma was used to measure quantitative outcomes, while semi-structured interviews captured subjective experiences. Findings revealed significant improvements in the experimental group across multiple dimensions of well-being, such as emotional, psychological, social, spiritual, physical, and self-awareness. Thematic analysis of qualitative data further highlighted benefits such as improved sleep quality, reduced stress and overthinking, academic readiness, inner peace, and stronger peer bonding. The study concludes that Anapanasati meditation is an accessible, low-cost, and non-invasive intervention with substantial potential to support adolescent well-being in school settings.