Grief is an intensely distressing and universally encountered phenomenon. It is an emotional and physiological response to loss, particularly due to the death of a close friend or relative. Despite the universality of grief, its expression and trajectories vary considerably across various cultures. This article explores grief through an interdisciplinary lens integrating physical, psychological, neuroscientific, and cultural perspectives. The psychological perspective examines grief’s emotional and cognitive dimensions, while the neuroscientific dimension explores brain mechanisms underlying grief. Cultural considerations highlight the diversity of mourning practices and beliefs across societies, demonstrating how sociocultural norms shape the expression and processing of grief. By integrating these perspectives, this article provides a comprehensive understanding of grief, informing therapeutic approaches and social support mechanisms. Additionally, different coping mechanisms such as journaling, therapy, breathwork, music and art, writing a letter to the deceased, and cognitive behavioral therapy (CBT) are discussed. The emerging role of digital platforms and AI in grief assessment and management has also been analyzed. This integrative exploration aims to inform more nuanced therapeutic interventions and social support systems by illuminating the impacts of grief on the mind, body, and society.