Introduction: Viral hepatitis, particularly hepatitis B, is a major public health problem due to its high transmissibility and severe complications. Chronic hepatitis B carries asignificant risk of fibrosis, cirrhosis and hepatocellular carcinoma, requiring rigorous biological monitoring based on serological markers. This study aims to describe theserological profiles of HBsAgpositive patients admitted to the Fann University Hospital Centre in 2024 and to assess the frequency of co-infections, particularly HBV/HCV.

Methodology: This was a prospective, descriptive and analytical study conducted at the Fann University Hospital over a one-year period from1January 2024 to 31 December2024. All HBVpositive patients seen for follow-up during the study period were included. Data were collected from records and test reports and entered into Excel.Thevariables collected were: age, sex, diagnosis, results: HBeAg, anti-HBeAb, total anti-HBcAb, anti-HBc IgM, anti-HCVAb and anti-HBsAb. Data analysis was performed usingExcel software. Descriptive analysis was performed using Epi Info 7®software.

Results: A total of 388 patients were included, 53% of whom were men, giving a male-tofemale ratio of 1.13. The average age of the patients was 37, ranging from 1 to 105 years. The 30-39 age group was the most represented (33.77%). The prevalence of HBeAg was 3.09%, the majority of whom were male (75%) and belonged to the 20-39 age group (58.33%). No patients had anti-HBc IgM. Anti-HCV antibodies were detected in 0.75% of carriers.

Conclusion: Despite the low prevalence of HBeAg and the absence of anti-HBc IgM, chronic HBV carriage remains a concern due to the risk of transmission and serious complications. These complications include cirrhosis and hepatocellular carcinoma. The results highlight the importance of strengthening awareness, screening, biological monitoring and vaccination.