Multiple Sclerosis (MS) is a non-communicable, chronic, and debilitating neurological disorder, predominately in women between the ages of 20 and 40. The underlying cause is unknown, with global incidence rising. Regions previously considered to have low or no incidence, are now reporting increasing incidence, notably, the sub-Saharan region.

Public health campaigns are shifting towards increased awareness and early detection. This is imperative in MS, as early diagnosis has been associated with reduced symptom severity and slower disease progression as it enables timely initiation of disease-modifying therapies (DMT).

Ultimately, improved awareness and early intervention could enhance the quality of life for individuals living with MS. Additionally, these measures could extend productive years and yield economic benefits at the individual and national level. This review highlights the urgent need for public awareness campaigns targeting MS in Nigeria.