Radiation shielding is an imperative as radiation can be serious concern within in such environment, where this environment can be either natural or man-made. The natural radiation source like solar wind that is consisting of Electron, Gamma, Protons, Neutrons, or Van Allen Belt, etc. while, the source of man-made is nuclear power facilities or either Exo- tmospheric or Endo-Atmospheric nuclear explosion. The effects of nuclear explosions produce both immediate and delayed destructive effects, that requires choice of right and proper protective materials for ICs to be shielded and survivable in such radiation environment driven by a nuclear weapon burst. Nuclear weapon effects in term of blast, thermal radiation, electromagnetic pulse, and prompt ionizing radiation, etc. are part of concerns for choosing the proper materials. Radiation shielding is based on the principle of attenuation, which is the ability to reduce a waves or ray’s effect by blocking or bouncing particles through a barrier material. This short review is discussing different holistic issues in respect to selected materials and integrated circuits in respect to survivability and shielding within a radiation environment, either man-made or natural.