Research Article

Arterial Restenosis: Past, Current Status and Future Directions

Authors: Arshed A. Kuchay, Alexander N. Lipin, Shoaib F. Padaria, Nikita N. Gruzdev, Aleksey G. Borisov, Hudayberdi A. Muhamedov.

DOI: 10.33425/3065-7059-1004

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Abstract

Relevance: Restenosis is a pathologic response to vascular injury, characterized by neointimal hyperplasia and progressive narrowing of a stented vessel segment. At present arterial restenosis is the main problem of endovascular surgery. The repeated development of vessel lumen narrowing reduces the use of open and percutaneous arterial reconstruction methods. Actually, restenosis itself is a narrowing of the vessel lumen by more than 50% after damage of the arterial wall in the process of its reconstruction, usually developing 6-9 months after angioplasty. Although advances in stent design have led to a dramatic reduction in the incidence of restenosis, it continues to represent the most common cause of target lesion failure following percutaneous coronary intervention. Efforts to maximize restenosis prevention, through careful consideration of modifiable risk factors and an individualized approach, are critical, as restenosis, once established, can be particularly difficult to treat. According to the literature, the incidence of restenosis in coronary arteries ranges from 10 to 40% depending on angiographic and clinical situations. The occurrence of restenosis in lower limb arteries ranges from 34 to 46% with balloon angioplasty and from 1.6 to 19.4% with stenting, respectively.\r\n\r\nAim: The aim of the study was to review and analyze modern literature data devoted to the problems of arterial restenosis in patients after arterial reconstructions in lower extremities and coronary arteries, and modern approach to the prevention of this problem.\r\n\r\nMaterial and Methods: We searched electronic databases including PubMed, Googleacademy, Cyberleninka, RSCI, HCC, Elibrary and Web of science with a search depth of 12 years for key aspects.

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