Toothache is a common problem occurring in the human population throughout the whole world. Toothache defined as an orofacial pain caused from a dental element or adjacent structures in consequence of several diseases or conditions, such as dental caries, periodontal disease, trauma, occlusal dysfunction, and abscess. There other factors behind toothache include tooth decay or fracture, abscessed tooth, and infected gums. There many species of bacteria inhabit the oral cavity such as toothache disease. Medicinal plants used as traditional treatments for numerous human diseases for thousands years in the world. Using of traditional medicine continues to expand rapidly across the world. In Africa, the dependence on traditional medicine to cure for many diseases such as toothache, and a shortage of drugs. Numerous reports published of the use of traditional plants and natural products for the treatment of toothaches. Effect of medicinal plants return to many parts such as leaves, roots, seeds and flower to toothache. The present review article cleared some traditional medicinal plants for toothache disease in the treatment of toothache.