The erector spinae plane (ESP) block is a recent and novel regional anesthesia procedure used primarily for the thoracic region. There is limited use of this block for the lumbar and sacral regions. Here we investigate the use of lumbar ESP blocks for three cases; hip disarticulation, penile burn, and perineal injury. For each case, an 18-gauge Tuohy needle was inserted into the paraspinous region at the L4 level and caudally directed towards the interfacial plane posterior to the transverse process via ultrasound. Once in place, 20-30 mL of 0.5% bupivacaine was injected. Opioid consumption was measured before and after block placement to evaluate for pain control. The ESP block yielded a significant reduction in opioid use for the penile burn and perineal injury cases, while a non-significant reduction was observed in the hip disarticulation case. The use of lumbar ESP block has shown the feasibility and effectiveness for sacral innervated injuries. This nerve block technique has strong potential to improve patient satisfaction and pain control while minimizing opioid reliance in the postoperative and traumatic injury recovery periods for lumbar and perineal injury patients.