Journal of Medical - Clinical Research & Reviews

Journal of Medical - Clinical Research & Reviews

Open Access
ISSN: 2639-944X
Original Research Article

Controlled Local Hyperthermia and Magnetic Hyperthermia for the Treatment Cancer Deseases

Authors: Zviad Kovziridze, Nunu Mitskevich, Sophio Badzgaradze, Guram Mentheshashvili, Paata Khorava, Anano Saldadze, Maia balakhashvili.

DOI: 10.33425/2639-944X.1478


Abstract

Average size of hematite and magnetite micro and nano powders and poly dispersity index, zeta potential and distribution of particles were studied. Analysis showed that average size of the obtained particles for magnetite is 740.9 nm, for hematite ultra-dispersive particles – 30-100 nm. Alternate current feed source was created for hyperthermia. Proceeding from the requirements of the objectives the U type MnZn material magneto conductors were selected, in which 10.0 and 8.0 mm width gaps were cut and glass test tubes with magnetite or hematite suspensions were placed in them. Series of experiments at various field intensity and frequencies showed that for efficient magnetic hyperthermia therapy more powerful device was needed with frequency of up to 10 Mega Hertz to achieve the temperature -42-45o C necessary for full activation of Neel and Brown mechanisms in particles.

At the next stage, on the basis of experimental material the anticancer mono-therapeutic effect of hyperthermia and its adjuvant action in poly chemotherapeutic treatment was presented by the use of a device created by us – “Lezi”. As a result of the experiment it was shown that in all animals (outbred albino mice, 3 months old) inhibition of cancer growth was fixed and intratumoral necrosis developed, while after 7 and 10 sessions tumors were ulcerated, which refers to positive effect of the experiment (Conclusion of Pathologic anatomical Laboratory “PATGEO”, Tbilisi, Georgia).

High anti-blastoma effect innovative technology was developed. Apparatus worked from 2019 on patients in oncological clinic “INTEGRA” Kutaisi for treating by “Cancerthermia” method. Received high results. The anti-cancer mono therapeutic effect and adjuvant action was proved in cancer polychemiotherapy. Creation of innovative technology of locally controlled “Cancerthermia” for treating patients.

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Citation: Zviad Kovziridze, Nunu Mitskevich, Sophio Badzgaradze, et al. Controlled Local Hyperthermia and Magnetic Hyperthermia for the Treatment Cancer Deseases. J Med - Clin Res & Rev. 2026; 10(6). DOI: 10.33425/2639-944X.1478
Editor-in-Chief
Sara Badia
Sara Badia
Cardiac Surgery Department | Germans Trias University Hospital in Pujol

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Impact Factor 1.84
Acceptance Rate 90%
Time to first decision 6-10 Days
Submission to acceptance 12-15 Days