Background: A key element of a geriatric patient is the problem of frailty. We generally identify a frail subject through sarcopenia, that is, the progressive reduction and thinning of the muscle mass. The sarcopenic subject falls because he cannot stand on his legs, including a whole series of endocrine, glucidic and neurological dysregulations that should have an extremely significant probability of falling.

Objective: The purpose of this article is, starting from pharmacological aspects of noa, to evaluate how to deal with a traumatized patient in the treatment with noa.

Methods: Both personal knowledge of pharmacology and the use of both paper books and international website databases such as pubmed, scopus, google scholar, researchgate were used to develop the article, typing in keywords such as "trauma coagulopathy" or "elderly patient treatment with noa" associated with specific compound names.

Conclusions: In an elderly subject who reports a head injury, even a mild one, we may find a chronic subdural hematoma that is so easily achieved due to cerebral atrophy, the greater excursion of the brain into the skull that tears the subdural vessels. In addition, why frequently the elderly subject takes the antithrombotic drug: cardioaspirin, warfarin, but above all the new oral anticoagulants.