Here we present a novel theory of reversing RAS/ EGFR mutation downstream activations and vicious cycle on activating oncosuppressors by inhibition of autophagy and induction of ferroptosis. The use of off label drugs and natural compounds specifically to target the genes involved in this pathway are explored and discussed. We present a case of treated patient with non small cell lung cancer using such approach successfully, and propose that application of such method can increase the survival of patients with RAS mutated tumors at least at hypothesis. Further clinical trials for lung cancer and other solid tumor types are recommended.