We report a case of refractory idiopathic thrombocytopenic purpura (ITP) in a patient with recurrent relapses despite conventional therapy, including corticosteroid tapering (deflazacort), adjuvant pimotimod (for recurrent infections and allergic rhinitis), and repeated intravenous immunoglobulin (IVIG) infusions. Platelet counts exhibited poor correlation with deflazacort dosing, and disease progression was complicated by allergic sensitization (Alternaria, bee venom), resulting in a torpid clinical course. Following limited response to standard therapies, an integrative approach was initiated using the natural supplement StemRegén (Aphanizomenon flos-aquae, AFA). After two months of oral administration, a progressive and sustained increase in platelet count was observed, with no significant adverse effects. This case suggests a potential immunomodulatory and platelet-stimulating effect of AFA, warranting further investigation into its role as an adjunctive therapy in refractory ITP. These findings highlight the need for exploring unconventional therapeutic strategies in patients with poor response to traditional treatments.