The work environment, associated with the lack of knowledge or professional fatigue, make the error something that the current ethical discussion cannot deepen. Since the publication of the report by The Institute of Medicine* (IOM) To Err Is Human: Building a Safer Health System (2000), errors related to medication administration, care-related infections, falls or pressure ulcers in the elderly are handled daily; with a high rate of complications for patients, families, professionals and health systems. Ethical principles must bring a high level of understanding and tolerance to the communication of error, but not your consent to failures. This environment must guarantee minimum working conditions and psychological safety for the improvement of practices, care quality and safety. Thus, a psychologically safe climate for work is envisaged, which promotes the reduction of safety incidents and increases productivity. Individual and collective talents emerge and make the environment conducive to adult learning. Given its importance, the work environment needs to be deeply analyzed, in order to identify factors that favor safe practices, as well as the human factors associated with this complex environment that intensify positive outcomes.