There is a disorder known as the increased cellular permeability syndrome that is a common cause of various chronic disorders. Though common, it is relatively unknown to most treating physicians. Excessive infiltration of irritants into various tissues can cause inflammation and pain, cause organ dysfunction leading to various symptoms, e.g., diarrhea, or infusion into smooth and skeletal muscle leading to disorders related to muscle dysfunction, or leaking out of substances from cells that should be contained, thus, causing urticaria, anaphylaxis, and edema. All these conditions have in common the fact that they all respond very well to treatment with dextroamphetamine sulfate despite resistance to standard therapy. The large majority of case reports and series have been reported in women. The present study demonstrates the efficacy of sympathomimetic therapy for a wide variety of clinical manifestations that were found in men. Several of the cases reported to improve greatly following dextroamphetamine sulfate treatment have never been previously reported in women.