Background: The coronavirus disease(COVID-19) is a highly transmittable and pathogenic viral infection cause severe acute respiratory syndrome and caused high morbidity and mortality among patients with different blood groups. This study aimed to determine the association between ABO blood groups and susceptibility to Covid-19 infection.

Material and Method: this was case control study, done on 100 of confirmed covid-19 patients and 100 control in Khartoum state, Sudan in the period between August to October 2020. Three ml of venous blood sample had been collected from each participant in the study, ABO blood groups were tested by monoclonal antisera.

Result: when compared ABO blood group between cases and control there was no association between blood groups and COVID-19 status, p-value 0.242 also There was no significant association between gender and ABO and Rhesus blood group, p-value 0.103, there is no significant association between presence of chronic illness and ABO and Rhesus blood group, p-value 0.558, There is no significant association between how they acquire the disease and ABO and Rhesus blood group, p-value 0.287.

Conclusion: The study revealed that ABO and RH blood groups, age, gender, chronic illnesses and source of infection had no association with susceptibility to infection with COVID -19 virus.