Microbiology & Infectious Diseases
Open AccessAdaptive Evolution of BabA Virulence Factor of Helicobacter pylori
Authors: Ting Yu, Lili Wang, Xiaona Xu, Mengchao Yu, Shuzhen Liang, Quanjiang Dong.
Abstract
Over half of the world's population suffers from Helicobacter pylori infection. However, the infection rate considerably varies across different countries and regions. Long-term Helicobacter pylori infection can pose serious health risks. Various outer membrane proteins synthesized by Helicobacter pylori participate in colonization, of which blood group antigen-binding adhesin is a key protein involved during the initial colonization process. Thus, this paper aimed to elucidate the adaptive evolution of BabA, a virulent factor of Helicobacter pylori, in human hosts from four aspects: the function of blood-group-anti-binding adhesin (BabA), the diversification of protein expression regulation, the effect of selection pressure on genes, and the relationship between gene evolution and diseases.
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