Introduction: Foot damage is one of the most serious complications of diabetes mellitus due to its functional and vital prognosis. The objective of this study is to determine the bacteriological profile and sensitivity of bacteria isolated from diabetic foot pus.

Methodology: This is a retrospective study of pus samples from diabetic foot wounds received by the laboratory between January 2017 and December 2021. Bacteria were identified based on their morphological, cultural, and biochemical characteristics. Antibiograms were performed using the agar diffusion method in accordance with CASFM recommendations. The data were analyzed using Excel software.

Results: A total of 86 diabetic foot pus samples were received, and 75 tested positive in culture, i.e., 87.20%. The most represented age group was 60 to 80 years old. Males predominated, accounting for 54.65% of cases, with a sex ratio of 1.20. Of the 92 strains isolated, the three most frequently encountered species were Proteus spp (22.88%), Staphylococcus aureus (20.65%), and Pseudomonas aeruginosa (14.13%). Meticillin resistance was observed in 57.8% of Staphylococcus aureus strains. Of the 56 strains of Enterobacteriaceae isolated, 26 were producers of extended-spectrum beta-lactamases (ESBL), representing 46.42%, with Klebsiella spp. being the most common.

Conclusion: The emergence of antibiotic resistance in bacteria is an additional problem for the treatment of patients with diabetic foot, hence the need for continuous monitoring of these resistances in the various healthcare facilities in Senegal.