Corynebacterium striatum is a gram-positive bacterium part of common flora of the human skin and mucous membranes. Plethora of data worldwide registers the pathogen a potent causative agent of invasive infection and nosocomial outbreaks in both immunocompromised and immuno-competent patients. Limited virulence factors of C. striatum have been reported in literature. C. striatum multidrug-resistant strains are here to stay. They provoke nosocomial invasive infections and outbreaks. The plasticity of the microorganism to acquire resistance via mobilizable resistance genes renders C. striatum a potent reservoir for naïve strains of other species. The ability to form biofilms is extra armor of the bacterium.