Microbiology & Infectious Diseases
Open AccessSeroprevalence and Serological Status of Cytomegalovirus Infection in Patients Received at the Medical Biology Laboratory of Pasteur Institute in Dakar from January 2018 to June 2020
Authors: Diop Abdou, Ndiaye Babacar, Diallo Thierno Abdoulaye, Mahou Chantal, Dubrous Phillippe, Seck Abdoulaye.
Abstract
Background: Cytomegalovirus (CMV) infection is the most common congenital infection worldwide and remains an important cause of neurological deficits and sensory hearing loss in developed countries. The seroprevalence of CMV infection is age-dependent and correlates with socio-economic level and ethnicity.
Objective: To study the seroprevalence and serological status of cytomegalovirus infection in patients received at the laboratory of the Pasteur Institute in Dakar.
Methodology: This retrospective study was conducted from January 2018 to June 2020. The determination of anti-CMV antibodies was carried out on the VIDAS 3 automated system (Biomérieux) by ELFA (Enzyme Linked Fluorescent Assay).
Results: A total of 418 patients were seen during the study period with a mean age of 30 years and extremes of 2 days and 74 years, the most represented age group was [30-39 years]. The seroprevalence of CMV was 97% with 3 patients presenting anti CMV IgM antibodies (0.7%). For pregnant women, CMV IgG antibodies were found in 139 patients, i.e. a prevalence of 97.3%. Only one pregnant woman was positive for CMV IgM antibody.
Conclusion: The high prevalence of CMV infection in the general population shows the problem of this viral pathology, hence the risk of contamination of immunocompromised persons and pregnant women, especially since its screening is not integrated among the routine examinations in our laboratories.
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