Duchenne Muscular Dystrophy is the result of mutation gene-dystrophine, product - protein-dystrophin presents in organism as the complexes proteins placing everywhere, their role unclear. Suppose all dystrophine complexes work as one functional System D, thanks signal ability complexes. Suppose the System D the ancient and appeared when the gene dystrophin-utrophin divided into two genes dystrophin and utrophin at early vertebrates. Perfect this System made the gene the longest in human genome. The surprising activity creatinkinase -21-23 000 ME, found by author, make to think of the damage much membranes - damage System. Destroy System D is beginning of the disease, finishing apoptosis - general destructive factor. Two factors determinate the disease –damage the system D and apoptosis.