Percutaneous Transluminal Coronary Angioplasty (PTCA) is one of the most widely accepted treatment modalities in patients with myocardial infarction. Although coronary angioplasty can prolong life, it can lead to several complications. This research aimed to determine the effectiveness of a structured teaching programme on knowledge regarding follow-up management of coronary angioplasty for patients who are undergoing coronary angioplasty in India. The selection for this research to be conducted in India is based on different aspects. For instance, India has a large population [1] that can help utilise the data and compare them with less populated countries, such as Kuwait, in future studies, considering socio-cultural aspects and their influence on knowledge. Hence, the selection of the sample from India is to facilitate the data collection process (selecting and recruiting participants conveniently). The objective of the research is to assess the knowledge on follow-up management of coronary angioplasty among patients undergoing coronary angioplasty, to assess the effectiveness of structured teaching programmes on follow-up management of coronary angioplasty among patients undergoing coronary angioplasty, and to find the association between the level of knowledge in relation to the selected demographic variable. Imogene King’s Theory of Goal Attainment has been used as a conceptual framework, and a pre- experimental one-group pre-test design was used in this research. The data was collected from 50 samples. Data was analysed using descriptive and inferential statistics. A significant difference between pre-test and post-test knowledge scores was found (mean difference = 12.1). The paired 1 test (t=19.59, p<0.01) shows that the score significantly increased, and the score is significant at a 0.01 level of significance. The research reveals that there is a significant improvement in the knowledge of patients on follow-up management of coronary angioplasty after a structured teaching programme.