Introduction: Child marriage mainly affects girls living in poorer rural areas and is on the rise in some locations, including Upper Egypt. The aim was to evaluate the effect of the primary prevention program of health consequences for early marriage among female adolescent students and conducted at two schools representing in a rural area in El-khosos district, El Qalubia Governorate. A quasi experimental design and a purposive sampling of 137 female students were at three grades of the selected schools. One tool was used for data collection were a self-administered questionnaire including socio demographic characteristics of students, students' knowledge related to early marriage health consequences, Perception of students toward adverse bio-psycho-social health consequences of early marriage and its' preventive procedures, assess female students' practices related to personal hygiene, nutrition and physical exercises during menstruation. 

Results: The study was concluded that the majority of students had unsatisfactory knowledge regarding early marriage health consequences preprogram while in post program more than two thirds of them had satisfactory knowledge with a highly statistically significant difference between their knowledge, healthy practices pattern and perception between pre and post primary prevention program implementation.

Conclusion: Primary prevention program reported a remarkable improvement in female students' knowledge, perception and health practices toward early marriage health consequences. Recommendations the study recommended that applying for health education programs among students in different educational settings focusing on early marriage health consequences with an implementation of practical training courses.