Ocular syphilis is a historical disease, which was considered only in the third world or developing countries and almost anecdotal, however, the achievements of recent years, thanks to debauchery and sexual freedom, have allowed it to permeate modern society. We present a 39-year-old male who goes for an eye examination for the f irst time with a 1-year history of depression, medicated by psychiatry with antidepressants, and with compound myopic astigmatism reported since childhood. He comes for the need to wear glasses, secondary to reporting significant visual loss gradually, with a predominance of the right eye (RE). The diagnosis and treatment are often at hand, cheaply and even free for most of the population, the challenge includes being able to suspect a young person, who does not present any specific characteristics and who subsequently debuts with skin lesions. In conclusion, thinking about the great simulator can save patients time, effort and a better prognosis in terms of their overall health.