Purpose: The aim of our study is to evaluate the effectiveness of Armenicum paste in the conservative treatment of early peri- implantitis.

Methods: This is a blinded RCT clinical prospective study of 47 patients diagnosed with early peri-implantitis who were treated from 2023 to 2025.

Study population: The patients’ age ranged from 32 to 64 years; 25 men and 22 women were included. The diagnosis of peri-implantitis was confirmed taking into account, indicators of bleeding on probing (BOP) > 20%, probing depth (PD) ≥ 4 mm, radiological signs of bone loss (MBL) ≥ 1 m. The study adheres to the CONSORT guidelines.

According to the selected treatment method, patients were randomly divided into two groups:

Group A (24 patients - 13 men and 11 women), 29 implant treatments included mechanical implant cleaning with titanium or plastic-curets, Air-Flow Perio Soft, irrigation of the circus-pocket with 0.12% chlorhexidine, additional use of local "Armenicum", past 10 days, and systemic antibiotics (amoxicillin 500mg and metronidazole) all the above antibiotics were administered per with duration
of 7 days.

Group B (23 patients - 10 men and 13 women), 28 implant treatments included mechanical implant cleaning with titanium or plastic-curettes, Air-Flow Perio Soft, irrigation of the circus-pocket with 0.12% chlorhexidine, and systemic antibiotics (amoxicillin 500mg and metronidazole) all the above antibiotics were administered per with duration of 7 days. The patient was under dynamic control, and professional hygiene was carried out.

To assess the effectiveness of treatment, the following clinical parameters were used:

1. Bleeding on probing (BOP);
2. Probing pocket depth (PPD) and both groups had comparable initial results before and after treatment.

Results: At each follow-up visit, biological and technical complications were assessed. There was a reduction in both PPD and BOP compared to baseline clinical measurements. Stable clinical scores of PPD and BOP were demonstrated after 6-month treatment initiation and remained stable over the next three years. The average BOP value in patients Group A before treatment for peri-implantitis was 2.5 ± 0.31. after 6 months, treatment month treatment 0.6 ± 0.24. The mean PPD in patients before treatment of peri-implantitis was 4.2 ± 0.24, after a 6-month treatment pocket was 3.1 ± 0.1(table 2). The average BOP value in patients Group B before treatment for peri-implantitis was 2.6 ± 0.42, after 6 months of treatment, 0.9 ± 0.29. The mean PPD in patients before treatment of peri- implantitis was 4.1 ± 0.45, after a 6-month treatment pocket was 3.8 ± 0.18. The mean BOP and PPD showed a statistically significant difference from baseline to 6 months (p≤0.05) in both Group A and Group B. however, mean BOP, PPD, the duction gain
was found to be greater in Group-A than in Group B (p ≤ 0.05).

Conclusion: Effective therapy for early peri-implantitis is systemic treatment of peri-implantitis with antibiotics, antiseptic treatment of peri-implant pockets and local application of "Armenicum" paste has shown its effectiveness and can prevent further development of peri-implantitis.