Aim: To retrieve and analyze the published information on the prevalence of Oral Squamous Cell Carcinoma (OSCC) in Mexico.

Methods: A search in several international and Latin-American databases was performed and all published studies providing data on the incidence of OSCC in the Mexican population were included. We excluded all case reports as well as those articles with confusing results or inconsistencies. Analyzed data were kind of institution age, gender, location and microscopic diagnoses.

Results: We found ten publications on the frequency of oral cancer in different Mexican populations. Recovered data derived from files of hospitals, universities, private histopathological diagnostic services and programs of the Mexican Secretary of Health. These data showed there were wide differences in frequencies on kind of analyzed population, age, gender, location and microscopic diagnoses.

Conclusions: In view of the scarce available information, it is essential to perform studies at national level using standardized criteria on the prevalence of OSCC. There are not enough and reliable data to support that the available information could reflect the true situation of this disease in Mexico.