Facial aging and pathological conditions impact both aesthetics and function. Facial adipostructuring a noninvasive technique using biomaterials to stimulate local adipose tissue is being explored for its applications in rejuvenation and tissue repair. This clinical case evaluates its effectiveness in a patient presenting with facial contraction due to an arachnoid cyst.

Methods: A Facestructure Kit (Mioface) was applied in three biweekly sessions, delivering specific solutions via cannulas into facial fat pads and interseptal spaces. Facial paralysis was assessed using the House-Brackmann scale, alongside patient-reported outcomes on mobility, pressure, spasm, and self-perception.

Results: Improvement in blepharospasm and facial contraction was observed after the first session, progressing from grade 3 to grade 1 on the House-Brackmann scale after the second session. At five months, improvement persisted (grade 2) with minor recurrence, suggesting the potential benefit of complementary therapies. The patient reported pressure relief, spasm control, and enhanced self-confidence.

Discussion: Facial adipostructuring may activate local regenerative cells (dWAT and SVF), promoting tissue repair. Although current literature is limited, activation of resident ADSCs is proposed as a key mechanism. Further research is needed to elucidate the cellular pathways involved and the specific role of dWAT.