Public transport in Nigeria and some other African countries is synonymous to road transport system as the government policy seems to give more attention to it than other modes. The few available bus operations in the country are second-hand rickety vehicles that are fossil-fuel dependent with all its negative health implications that tend to catalyze SARS-CoV-2 otherwise known as COVID-19 infection that has ravaged the whole world at a pandemic scale. The spatial spread of the virus is mass transport related. This study therefore using direct observatory and internet-based review of literature method to examine the physical state of urban public transport infrastructure adaptation to the new challenges of COVID-19 and its variance. The study revealed that the use of vehicular and terminal retrofitting through IT based social-distancing before and after boarding, and the use of environmental friendly vehicles in line with the global crusade for smart city and green mobility is the panacea to the global epidemiology. African countries like Nigeria should therefore awake from their slumber and join the race toward green mobility and smart city to curtail the spread of epidemic viruses.