Stem Cell and Regenerative Medicine
Open AccessThe Cure of Human Type 2 Diabetes via Systematic Transplantations of dgHPSCs Overexpressing Human ERR? and Insulin Genes (II)
Authors: Taihua Wang, Xiaohui Cui, Rongrong Li, Xinyi Shi, Xiaoxia Jiang, Shufeng Du, Mengqian Wang, Cancan Zhang, Wenxia Li, Linyu Cui, Limin Zhang, Guoke Yang, Ying Meng, Gang Zhang.
Abstract
We previously reported the cure of human type 2 diabetes (T2D) via transplantations of directly-generated human pluripotent stem-like cells (dgHPSCs) overexpressing human insulin (INS) and estrogen-related receptor γ (ERRγ) genes. Our strategy not only can completely replace the daily insulin injections of the patients, but also can potentially repair the complications of T2D patients. Here, we reported the cure of another patient case with similar treatments. This patient treated his T2D by daily taking Gliclazide Modified Release Tablets and Acarbose Tablets. After 19 times of transplantations of dgHPSCs, he stopped taking the medications completely, and his glucose levels were remained around normal levels during the past more than three years. In addition, the patient’s liver function was also improved obviously. Therefore, this investigation is another vivid example for the cure of human T2D with our strategy
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