The greatest dilemma of human pluripotent stem cell transplantation therapy clinically is the potential risk to form teratomas in the recipient’s body. On the one hand, to date, no data can confirm this risk. On the other hand, no data can confirm the safety of human pluripotent stem cell transplantations, either. To break this dilemma, the correspondence author, G Z, decided to accept human pluripotent stem cell transplantations voluntarily. During the past five years, G Z accepted totally 77 times human stem cell transplantations with/without overexpressing different human genes, and the whole number of human stem cells was up to approximately 6.36 X 109 . After medical examinations, the results demonstrated that G Z’s health conditions were basically normal. Thus, our investigations preliminarily proved that intravenous transplantations of human pluripotent stem cells were safe so far, at least for this case.