Research Article

C-Reactive Protein as Predictor of Acute Cholangitis in Patients with Acute Calculous Cholecystitis

Authors: Jael R García-Romo, Adolfo Cuendis-Velazquez, Alejandra Nuñez-Venzor.

DOI: 10.33425/2689-1093.1086

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Abstract

Objective: Identify a marker of systemic inflammatory response that predicts acute cholangitis in patients with acute calculous cholecystitis.

Materials and Methods: Cross-sectional and retrospective study of patients with acute calculous cholecystitis who underwent endoscopic retrograde cholangiopancreatography for clinical diagnosis of acute cholangitis. Group A was obtained with 24 patients with acute calculous cholecystitis and acute suppurative cholangitis, and group B of 24 patients with acute calculous cholecystitis without acute suppurative cholangitis.

Results: A cut-off point of 34 years was obtained for a sensitivity, specificity and AUC for the diagnosis of acute suppurative cholangitis in patients with acute calculous cholecystitis of 95%, 41% and 74% (p=0.003), respectively, 83%, 79% and 86% (p=<0.001) for a C-reactive protein, respectively, with a cut-off point of 10.3 mg/dl, and 83%, 62% and 72% (p=0.007) for a neutrophil-lymphocyte ratio, respectively, for a cut-off point of 6.7.

Conclusion: C-reactive protein is the systemic inflammatory response marker with the greatest predictive capacity for acute cholangitis in acute calculous cholecystitis.

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