Background: The indications of splenectomy and its ways to perform are today well coded. Recognizing the risks of fulminant infections and discoveries in the field of surgical techniques, in anesthesia but also in hematology and oncology, have reduced morbidity and mortality rate after total or partial splenectomy, regardless of the disease for which it was indicated.

Case Presentation: The article aims to present two cases of splenectomy performed in special conditions: spleen lesion operated laparoscopically in child and splenectomy in case of extreme splenomegaly, with the revision of the specialized literature.

Conclusion: Laparoscopic splenomectomy is feasible in case of splenic trauma, provided that the condition of the patient is stable and a well-trained team and high-performance medical equipment are available. In the case of splenomegaly, the adhesions and the branching of the spleen vessels make the difference between easy and difficult splenectomy.