Aims: To investigate the recent prevalence of MRSA S. aureus from clinical samples in a hospital and to evaluate their antibiotic resistance pattern.

Material and Methods: The study comprised 258 coagulase-positive staphylococci (COPS), isolated from a total of 25059 clinical specimens (like pus, blood, urine, sputum, vaginal swab, etc.) patients in the hospital for duration of 1 year. The bacteriological investigation was done according to the standard laboratory procedure and antimicrobial susceptibility testing was performed.

Results: During this time 258 samples of S. aureus were isolated. Out of which a total no. of 111 were cefoxitin resistant (MRSA) and remain the number of 147 isolates were cefoxitin sensitive (MSSA).

Conclusion: In many hospitals, one of the most common causes of therapeutic problems is MRSA. The MSSA isolates were more frequent than MRSA and also MRSA was multidrug-resistant compare to MSSA. Vancomycin and linezolid can be reserved drugs for life-threatening infections and also for treating multidrug-resistant MRSA infections.