Acute organ dysfunction, haematologic changes and changes in coagulation are present in virtually all patients with sepsis associated with community acquired pneumonia. We were able to diagnose sepsis linked to community acquired pneumonia in 218 patients, based on typical symptoms and changes in laboratory values from the period of 2012–2020. We examined the frequency and severity of anaemia, quantitative and qualitative changes of leukocytes, numerical abnormalities of platelets, and clinical and laboratory signs of coagulopathy. We diagnosed anaemia of variable severity in 149 cases with sepsis and in 161 patients with leukocytosis. Extremely severe leukocytosis was diagnosed in 6 patients. Variably severe decreases in the number of leukocytes (leukopenia, agranulocytosis) were detected in 33 cases. Leukemoid reaction with increased leukocyte count, myelocytes, metamyelocytes and some atypical myeloid cells in the peripheral blood was diagnosed in 3 patients. Based on platelet counts we detected thrombocytopenia in 82 patients. Myelodysplastic bone marrow characteristics was revealed in one patient after performing biopsy with a Jamshidi needle. Disseminated intravascular coagulation was diagnosed in 6 patients based on typical clinical signs and laboratory tests of the coagulation system.