Neurofibromatosis is a multisystemic genetic disorder characterized by the development of benign and malignant nervous system tumors, including spinal neurofibromas that can cause significant neurological compromise. Among its rare complications, cervical compressive myelopathy represents a potentially disabling condition that demands early diagnosis and timely surgical intervention. We report the case of a 33-year-old male with a known history of neurofibromatosis who presented with progressive weakness, loss of strength, and spasticity, in whom magnetic resonance imaging revealed multiple cervical neurofibromas causing spinal cord compression from C2 to C4. The patient underwent cervical laminectomy with partial tumor resection, resulting in postoperative neurological improvement. This case underscores the importance of early recognition of neurological symptoms in neurofibromatosis, the essential role of advanced imaging for diagnosis, and the need for a multidisciplinary management approach involving neurology, neurosurgery, rehabilitation, and genetics to optimize functional outcomes and quality of life.