Research Article

Mixed Pulmonary Hypertension: HIV Infection as an Underlying Cause

Authors: Ricardo Donado-Botero, Ingrid Tibocha-Gordón, Mario Montoya-Jaramillo, Isabella MesaBeltran, Karol Mendoza-Leottau, Karina Ibañez-Sanchez, Maria Camila Benitez-Escobar, Andrea Jimenez-Petro, Elían Macias-Posada, Mari Rosa Salaiman-Serpa, María Auxiliadora Cuello Rojas, Orlando Naranjo-Lorduy.

DOI: 10.33425/2771-5906.1042

---

Abstract

In the context of HIV infection, pulmonary hypertension (PH) represents an uncommon but clinically significant complication, particularly when mechanisms corresponding to Groups 1 and 4 coexist. We present the case of a 50-yearold male patient with well-controlled HIV and a history of pulmonary tuberculosis, who presented with progressive dyspnea, initially suspected to be a tuberculous reactivation. A chest CT scan revealed a cavitary pulmonary lesion and an organized lobar thrombus, findings later confirmed by right heart catheterization, which showed parameters consistent with precapillary PH. Catheter-directed thrombolysis was performed using the EKOS® system, resulting in favorable clinical evolution without adverse events. Subsequently, initiation of targeted vasodilator therapy was planned. To our knowledge, this is the first case reported in Colombia describing the use of the EKOS® system in an HIV-positive patient with mixed PH. This therapeutic approach offers a safe and effective alternative in complex clinical settings with limited resources, such as those in the Caribbean region. The case highlights the importance of early hemodynamic assessment and of therapeutic strategies tailored to regional contexts.

View / Download PDF