Case Report

Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) in the Setting of Renal Cell Carcinoma in a Native American/American Indian Patient

Authors: Seth Jones, Prashant Kaushik, Mark Bannon, Stephen T. Bastible, Ali Khan, Harsh Patel.

DOI: 10.33425/2771-5906.1027

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Abstract

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare inflammatory arthritis characterized by pitting edema and symmetric synovitis of hands and feet. The condition is typically treated by steroids, with an excellent clinical response. The relapsing and remitting nature of the disease, along with shared similarities with other rheumatic disorders often serve as a challenge to establishing a diagnosis. It is frequently categorized as a paraneoplastic syndrome due to the association of the condition with both hematologic malignancy and solid tumors. We present a case of an elderly Native American / American Indian male (NA/AI) with RS3PE diagnosed in the setting of renal cell carcinoma (RCC).

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