Womens Health Care and Issues
Open AccessEffect of Hemolysis Products in the Development of Events After Coronary Artery Bypass Grafting
Authors: Maksimovich Yelizaveta.
Abstract
According to the degree of intraoperative hemolysis (IOH), determined by the level of free hemoglobin, Hbfree, patients after coronary artery bypass grafting (CABG) were divided into 3 groups: group 1 - without IOH (Hbfree ≤0.1 g/l), n=43, group 2 - with low IOH (lIOH) with Hbfree >0.1 g/l and <0.5 g/l, n=42, group 3 with high IOH (hIOH) - Hbfree ≥0.5 g/l, n=38. The study of changes in iron levels was carried out on the basis of determining the content of serum iron (Fesyv.), transferrin (Tr), total iron-binding capacity of serum (TIBC), latent iron-binding capacity of blood, LIBC, ferritin (F) in blood plasma. The NO level was determined by the total concentration of nitrites and nitrates in blood plasma – NOx. In patients with intraoperative hemorrhagic pulmonary disease, the change in the parameters was maximum: an increase in [Fesyv.] by 91.9%, p <0.001, [F] – by 165.9% (p <0.001), a decrease in [Tr] – by 22.0%, p <0.001 and [LVSS] – by 45.0% p <0.001. The revealed changes in the iron pool parameters in patients with coronary artery bypass grafting indicate the effect of iron on the activity of oxidative processes, predisposing to the development of complications. This is confirmed by the nature of the change in the concentration of nitrites and nitrates, which depended on the severity of intraoperative hemolysis, indicating the effect of hemolysis products, including iron, on the processes of formation and utilization of nitric oxide.
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